5α-Androstane-3α,17α-diol CAS 6165-21-5 With Best Price

Chemical Properties:

 Introduction  

5α-Androstane-3α,17α-diol (CAS 6165-21-5) is a synthetic steroid derivative that has garnered significant attention in pharmaceutical, cosmetic, and biochemical research industries. With a molecular formula of C₁₉H₃₂O₂ and a molecular weight of 292.46 g/mol, this compound belongs to the androstane family, characterized by its unique stereochemical configuration. Its distinct structural properties enable diverse applications, ranging from hormone therapy intermediates to advanced cosmetic formulations. This article explores the multifaceted applications of 5α-Androstane-3α,17α-diol and highlights the manufacturing expertise of leading companies in producing high-purity, research-grade compounds for global markets.  

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   Chemical Structure and Properties  

5α-Androstane-3α,17α-diol is a dihydroxy derivative of androstane, featuring hydroxyl groups at the 3α and 17α positions. The compound’s rigid steroidal backbone and stereospecific hydroxyl groups contribute to its bioactivity and stability. Key physicochemical properties include:  

-  Melting Point : ~200–205°C  

-  Solubility : Soluble in organic solvents (e.g., ethanol, DMSO) but poorly soluble in water.  

-  Storage : Stable under inert conditions at –20°C.  

The compound’s synthetic versatility allows modifications to enhance bioavailability or target-specific interactions, making it valuable for industrial and academic applications.  

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   Applications of 5α-Androstane-3α,17α-diol  

     1.  Pharmaceutical Industry   

5α-Androstane-3α,17α-diol serves as a critical intermediate in the synthesis of steroidal drugs. Its structural similarity to endogenous hormones enables its use in developing:  

-  Anti-inflammatory Agents : Derivatives of this compound have shown potential in modulating glucocorticoid receptors, offering pathways for treating chronic inflammation.  

-  Hormone Replacement Therapies (HRT) : As a precursor, it aids in synthesizing androstanediols and other hormones used in addressing androgen deficiencies.  

-  Neuroprotective Research : Recent studies explore its role in mitigating neurodegenerative disorders due to its interaction with neurosteroid pathways.  

     2.  Cosmetic and Dermatology Formulations   

The compound’s anti-aging and skin-rejuvenation properties have propelled its adoption in premium skincare products:  

-  Collagen Synthesis : Enhances collagen production, reducing wrinkles and improving skin elasticity.  

-  Anti-Acne Solutions : Regulates sebum production by interacting with androgen receptors in sebaceous glands.  

-  Topical Delivery Systems : Its lipophilic nature allows efficient penetration into skin layers, making it ideal for serums and creams.  

     3.  Biochemical Research   

As a reference standard, 5α-Androstane-3α,17α-diol is indispensable in:  

-  Metabolic Pathway Studies : Investigating steroidogenesis and hormone metabolism.  

-  Enzyme Inhibition Assays : Used to study 5α-reductase and 17β-hydroxysteroid dehydrogenase activities.  

-  Drug Discovery : High-purity batches enable screening for novel therapeutics targeting hormonal disorders.  

     4.  Veterinary Medicine   

In veterinary applications, the compound aids in developing treatments for hormonal imbalances in livestock and companion animals.  

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   Manufacturing Excellence: Key Advantages of Leading Producers  

Companies specializing in the production of 5α-Androstane-3α,17α-diol distinguish themselves through advanced synthesis techniques, stringent quality control, and customer-centric services. Below are the core strengths of top-tier manufacturers:  

     1.  State-of-the-Art Synthesis Technology   

Leading manufacturers employ  asymmetric synthesis  and  enzymatic catalysis  to achieve high stereochemical purity. By optimizing reaction conditions (e.g., temperature, solvent systems), they ensure yields exceeding 95%, minimizing waste and production costs.  

     2.  Scalability and Customization   

-  Large-Scale Production : Facilities equipped with multi-kilogram reactors meet bulk demands from pharmaceutical clients.  

-  Custom Synthesis : Tailored modifications (e.g., isotopic labeling, derivatization) support niche research needs.  

     3.  Quality Assurance and Regulatory Compliance   

-  Analytical Precision : Utilization of HPLC, GC-MS, and NMR ensures ≥98% chemical purity.  

-  GMP/ISO Certification : Compliance with international standards guarantees product consistency and safety.  

-  Stability Testing : Long-term studies validate shelf life under recommended storage conditions.  

     4.  Sustainable Practices   

Eco-conscious manufacturers adopt green chemistry principles:  

-  Solvent Recycling : Reduces environmental footprint.  

-  Biocatalysis : Lowers energy consumption compared to traditional methods.